Higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients might be correlated with inhibition of Type I IFN signaling

Abstract Background Chemokine levels in severe coronavirus disease 2019 (COVID-19) patients have been shown to be markedly elevated. But the role of chemokines mild COVID-19 has not yet established. According epidemiological statistics, most cases Shiyan City, China, mild. The purpose this study was evaluate level and explore correlation between host immune response. Methods In study, we used an enzyme-linked immunosorbent assay detect serum City. Expression chemokine receptors other signaling molecules measured by real-time polymerase chain reaction. Results We first demonstrated that patients, both sever cases, are characterized higher chemokines. Specifically, monocyte chemotactic protein 1 (MCP-1) is expressed at COVID-19. receptor MCP-1, C-C type 2, patients. Finally, observed a significant negative expression interferon (IFN) regulatory factor 3 (IRF3) MCP-1 Conclusion Higher might correlated with inhibition IFN signaling. finding adds our understanding immunopathological mechanisms acute respiratory syndrome 2 infection provides potential therapeutic targets strategies.